In order for vitamins to be utilized by the body, they must first be converted into their active coenzyme forms. COENZYMATED? B-1 is ready to go to work immediately. This essential nutrient plays key roles in generating energy from carbohydrates, fats, and alcohol, and in the formation of neurotransmitters in the brain. Thiamin diphosphate (TDP), also called thiamin pyrophosphate (TPP) or cocarboxylase, is the active, coenzyme form of vitamin B-1.